吉利彩票投注

抗体 > 多克隆抗体 > SUN2 Antibody
  • 产品类型:
    Polyclonal Antibody
  • 产品名称:

    SUN2 Antibody

  • 货号:
    CSB-PA883386LA01HU
  • 规格:
    ¥1200
  • 别名:
    SUN2 antibody; FRIGG antibody; KIAA0668 antibody; RAB5IP antibody; UNC84B antibody; SUN domain-containing protein 2 antibody; Protein unc-84 homolog B antibody; Rab5-interacting protein antibody; Rab5IP antibody; Sad1/unc-84 protein-like 2 antibody
  • 种属:
    Homo sapiens (Human)
  • 免疫原:
    Recombinant Human SUN domain-containing protein 2 protein (45-155AA)
  • 宿主:
    Rabbit
  • 种属反应性:
    Human, Mouse, Rat
  • 应用范围:
    ELISA, WB, IHC; Recommended dilution: WB:1:500-1:5000, IHC:1:200-1:500
  • 背景:
    As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Required for nuclear migration in retinal photoreceptor progenitors implicating association with cytoplasmic dynein-dynactin and kinesin motor complexes, and probably B-type lamins; SUN1 and SUN2 seem to act redundantly. The SUN1/2:KASH5 LINC complex couples telomeres to microtubules during meiosis; SUN1 and SUN2 seem to act at least partial redundantly. Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. May also function on endocytic vesicles as a receptor for RAB5-GDP and participate in the activation of RAB5.
  • 克隆类型:
    Polyclonal
  • 抗体亚型:
    IgG
  • 纯化方式:
    >95%, Protein G purified
  • 标记方式:
    Non-conjugated
  • 保存缓冲液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式:
    Liquid
  • 储存条件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 图片:


    Western Blot

    Positive WB detected in: Jurkat whole cell lysate, Rat lung tissue, Mouse liver tissue

    All lanes: SUN2 antibody at 4.5µg/ml

    Secondary

    Goat polyclonal to rabbit IgG at 1/50000 dilution

    Predicted band size: 81, 83, 80 kDa

    Observed band size: 81 kDa



    IHC image of CSB-PA883386LA01HU diluted at 1:200 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.



    吉利彩票投注IHC image of CSB-PA883386LA01HU diluted at 1:200 and staining in paraffin-embedded human prostate tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

  • 说明书:
  • Accession No。:
  • 指标名称:
    SUN2
  • 研究领域:
    Tags & Cell Markers