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ACOT7 Antibody

Datasheet
  • 货号:
    CSB-PA001169GA01HU
  • 规格:
    ¥4,100
  • 其他:

产品详情

  • Uniprot No.:
  • 基因名:
    ACOT7
  • 别名:
    ACH1 antibody; ACOT 7 antibody; ACOT7 antibody; ACT antibody; Acyl CoA thioesterase 7 antibody; Acyl CoA thioesterase long chain antibody; Acyl-CoA thioesterase 7 antibody; BACH antibody; BACH_HUMAN antibody; Brain acyl CoA hydrolase antibody; Brain acyl-CoA hydrolase antibody; CTE-II antibody; CTE-IIa antibody; Cytosolic acyl coenzyme A thioester hydrolase antibody; hBACH antibody; LACH antibody; LACH1 antibody; Long chain acyl-CoA thioester hydrolase antibody
  • 宿主:
    Rabbit
  • 反应种属:
    Human,Mouse,Rat
  • 免疫原:
    Human ACOT7
  • 免疫原种属:
    Homo sapiens (Human)
  • 抗体亚型:
    IgG
  • 纯化方式:
    Antigen Affinity purified
  • 浓度:
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液:
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20℃, Avoid freeze / thaw cycles.
  • 产品提供形式:
    Liquid
  • 应用范围:
    ELISA,WB,IHC
  • Protocols:
  • 储存条件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

靶点详情

  • 功能:
    Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. May play an important physiological function in brain. May play a regulatory role by modulating the cellular levels of fatty acyl-CoA ligands for certain transcription factors as well as the substrates for fatty acid metabolizing enzymes, contributing to lipid homeostasis. Has broad specificity, active towards fatty acyl-CoAs with chain-lengths of C8-C18. Has a maximal activity toward palmitoyl-CoA.
  • 基因功能参考文献:
    1. PKCzeta was specifically involved in ACOT7 depletion-mediated cell cycle arrest as an upstream molecule of the p53-p21 signaling pathway in MCF7 human breast carcinoma and A549 human lung carcinoma cells.
    2. WIG1 governs the miRNA-dependent and the miRNA-independent recruitment of AGO2 to lower the stability of and suppress the translation of ACOT7 mRNA.
    3. the human BACH gene can express long-chain acyl-CoA hydrolase activity in multiple intracellular compartments by generating BACH isoforms with differential localization signals to affect various cellular functions that involve acyl-CoAs
    4. BACH was deranged in hippocampus of mesial temporal lobe epilepsy patients.
  • 亚细胞定位:
    Isoform 4: Cytoplasm, SUBCELLULAR LOCATION: Isoform 6: Cytoplasm, SUBCELLULAR LOCATION: Isoform 1: Mitochondrion, SUBCELLULAR LOCATION: Isoform 5: Mitochondrion
  • 组织特异性:
    Isoform 4 is expressed exclusively in brain.
  • 数据库链接:

    HGNC:

    OMIM:

    KEGG:

    STRING:

    UniGene:



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